Umbilical cord (UC) derived Peripheral Blood Mononuclear Cells (PBMCs) are rich in immature immune cells, especially naive T-cells, offering high viability (often >90% post-thaw with good cryopreservation) and potential for therapies beyond hematopoietic stem cell transplantation (HSCT), like NK cell or T-cell therapies, though quantity can be a limitation, making cell processing crucial for quality and clinical application, with factors like collection method and storage impacting overall cell counts and functionality.
Key Aspects of hMSC Cultures:
Immature Immune Cells:
UC blood is a significant source of hematopoietic stem cells (HSCs) and contains a high proportion of naive T-cells (around 90%), which haven’t encountered antigens, making them ideal for immune reconstitution.
High Viability:
Properly processed and cryopreserved UC blood often shows excellent post-thaw viability, frequently exceeding 90%, with some studies showing >99% viability immediately after processing.
Cellular Composition:
It’s rich in Hematopoietic Stem Cells (HSCs) (CD34+ cells) and Natural Killer (NK) cells, offering potential for various cellular therapies
For more details, contact our team at bd@cell-bio.life
